Friday, 4 September 2015

House of Cards


Apart from the issue of interaction with the so-called ‘Junk’ DNA which makes up around 98% of the genome (which was only considered to be junk because no one had worked out what it did), splicing powerful genetic functionality together from disparate sources is alien to the diverse genepool of life that has evolved over billions of years, and if unleashed upon this genepool it will, over time, distort and mutate myriad species as it propagates through the delicate mesh of interconnected systems which maintain our very existence.  The threat of unintended consequences has never been so clearly etched upon the hubris of mankind…

Thus, just as with other keys to fundamental powers of nature such as nuclear fission and fusion, genetic manipulation has the power to kill or cure on a vast scale.  One could be easily argue that its potential to heal or harm is even more extreme.  It is clearly up to man to ensure that he has the wisdom and long-sightedness to avoid the existential threats that genetic manipulation can pose through unintended consequences over the longer term in particular.

DNA is the fundamental code that defines all lifeforms, providing the framework and tools which have allowed the evolution of life into its myriad interconnected forms over hundreds of millions of years.  Even seemingly minor alterations of the genetic code of life can produce potentially catastrophic unforeseen side-effects which can then be faithfully transmitted down the generations and propagated out into the genepool over millennia as life continues to evolve and adapt. 

Unlike the natural random mutations which act as ‘dither’ signals, allowing organisms to delicately and sensitively evolve within ever changing environments, these manually purposed ‘mutations’ have the potential to distort and degrade the evolutionary process over time and propagate like ripples through the environment.  The resultant adjustments effectively imprint the distortion – which is often completely unrelated to the organism’s environment – upon the DNA of other organisms which come into contact with it. 

Clearly this process has the potential to degrade the fitness and biodiversity of other lifeforms; first in the local environment and then spreading out year on year into other bio-systems worldwide.  In the highly non-linear and complex web of interactions that is normally manipulated by the environment driving evolution through random mutations, the manual ‘mutation’ itself is attempting to drive the environment, with the resultant disturbance potentially propagating out chaotically via the so-called ‘butterfly effect.’ 

The manual modification of genes is powerful indeed, but the full true cost and impact upon the integrity and stability of life could take many millennia to unfold or just a few years.  With this is mind, it is quite literally vital that extremely stringent and robust control mechanisms are put in place in order to prevent contamination of the world’s genepool by ill thought out expressions of man’s stupidity and short-sightedness.